Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3320634..3321254 Replicon chromosome
Accession NZ_CP117402
Organism Salmonella enterica subsp. enterica serovar Give strain RM007

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ13_RS16345 Protein ID WP_001280991.1
Coordinates 3321036..3321254 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ13_RS16340 Protein ID WP_000344807.1
Coordinates 3320634..3321008 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ13_RS16330 (3315773) 3315773..3316966 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ13_RS16335 (3316989) 3316989..3320138 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ13_RS16340 (3320634) 3320634..3321008 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ13_RS16345 (3321036) 3321036..3321254 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ13_RS16350 (3321433) 3321433..3321984 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQQ13_RS16355 (3322102) 3322102..3322572 + 471 WP_000136183.1 YlaC family protein -
PQQ13_RS16360 (3322628) 3322628..3322768 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ13_RS16365 (3322774) 3322774..3323034 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ13_RS16370 (3323259) 3323259..3324809 + 1551 WP_023230872.1 EAL domain-containing protein -
PQQ13_RS16380 (3325040) 3325040..3325429 + 390 WP_023230873.1 MGMT family protein -
PQQ13_RS16385 (3325462) 3325462..3326031 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271184 WP_001280991.1 NZ_CP117402:3321036-3321254 [Salmonella enterica subsp. enterica serovar Give]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271184 WP_000344807.1 NZ_CP117402:3320634-3321008 [Salmonella enterica subsp. enterica serovar Give]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References