Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 815976..816636 Replicon chromosome
Accession NZ_CP117402
Organism Salmonella enterica subsp. enterica serovar Give strain RM007

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I1G658
Locus tag PQQ13_RS03955 Protein ID WP_001727955.1
Coordinates 816223..816636 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ13_RS03950 Protein ID WP_000351186.1
Coordinates 815976..816242 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ13_RS03930 (811904) 811904..813337 - 1434 WP_023217487.1 6-phospho-beta-glucosidase BglA -
PQQ13_RS03935 (813496) 813496..813807 + 312 WP_023217488.1 N(4)-acetylcytidine aminohydrolase -
PQQ13_RS03940 (813971) 813971..814630 + 660 WP_000250289.1 hemolysin III family protein -
PQQ13_RS03945 (814746) 814746..815726 - 981 WP_000874169.1 tRNA-modifying protein YgfZ -
PQQ13_RS03950 (815976) 815976..816242 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ13_RS03955 (816223) 816223..816636 + 414 WP_001727955.1 protein YgfX Toxin
PQQ13_RS03960 (816689) 816689..817210 - 522 WP_001055885.1 flavodoxin FldB -
PQQ13_RS03965 (817323) 817323..818219 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ13_RS03970 (818243) 818243..818956 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ13_RS03975 (818962) 818962..820695 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16201.18 Da        Isoelectric Point: 10.7537

>T271178 WP_001727955.1 NZ_CP117402:816223-816636 [Salmonella enterica subsp. enterica serovar Give]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT271178 WP_000351186.1 NZ_CP117402:815976-816242 [Salmonella enterica subsp. enterica serovar Give]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1G658

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References