Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4267085..4267601 Replicon chromosome
Accession NZ_CP117400
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM014

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQP96_RS20960 Protein ID WP_000220578.1
Coordinates 4267085..4267369 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP96_RS20965 Protein ID WP_000212724.1
Coordinates 4267359..4267601 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP96_RS20945 (4262297) 4262297..4263949 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
PQP96_RS20950 (4264358) 4264358..4266496 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP96_RS20955 (4266617) 4266617..4267081 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP96_RS20960 (4267085) 4267085..4267369 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP96_RS20965 (4267359) 4267359..4267601 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP96_RS20970 (4267679) 4267679..4269592 - 1914 WP_001212137.1 BglG family transcription antiterminator -
PQP96_RS20975 (4269609) 4269609..4270349 - 741 WP_000779263.1 KDGP aldolase family protein -
PQP96_RS20980 (4270346) 4270346..4271464 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP96_RS20985 (4271448) 4271448..4272581 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T271172 WP_000220578.1 NZ_CP117400:c4267369-4267085 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271172 WP_000212724.1 NZ_CP117400:c4267601-4267359 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References