271168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3532034..3532654 Replicon chromosome
Accession NZ_CP117400
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM014

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP96_RS17485 Protein ID WP_001280991.1
Coordinates 3532436..3532654 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP96_RS17480 Protein ID WP_000344807.1
Coordinates 3532034..3532408 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP96_RS17470 (3527173) 3527173..3528366 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP96_RS17475 (3528389) 3528389..3531538 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP96_RS17480 (3532034) 3532034..3532408 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP96_RS17485 (3532436) 3532436..3532654 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP96_RS17490 (3532833) 3532833..3533384 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP96_RS17495 (3533501) 3533501..3533971 + 471 WP_000136181.1 YlaC family protein -
PQP96_RS17500 (3534027) 3534027..3534167 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP96_RS17505 (3534173) 3534173..3534433 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP96_RS17510 (3534658) 3534658..3536208 + 1551 WP_000213139.1 EAL domain-containing protein -
PQP96_RS17520 (3536439) 3536439..3536828 + 390 WP_000961285.1 MGMT family protein -
PQP96_RS17525 (3536861) 3536861..3537430 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271168 WP_001280991.1 NZ_CP117400:3532436-3532654 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271168 WP_000344807.1 NZ_CP117400:3532034-3532408 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References