Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 971555..972047 Replicon chromosome
Accession NC_017618
Organism Streptococcus suis JS14

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag SSUJS14_RS04810 Protein ID WP_011922404.1
Coordinates 971555..971812 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag SSUJS14_RS04815 Protein ID WP_012775104.1
Coordinates 971796..972047 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUJS14_RS04790 967180..968250 + 1071 WP_012775101.1 tyrosine recombinase XerS -
SSUJS14_RS04795 968320..969837 - 1518 WP_014636393.1 phosphoglucomutase -
SSUJS14_RS04800 969913..970854 - 942 WP_012775102.1 sensor histidine kinase -
SSUJS14_RS04805 970851..971516 - 666 WP_012775103.1 response regulator transcription factor -
SSUJS14_RS04810 971555..971812 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUJS14_RS04815 971796..972047 - 252 WP_012775104.1 hypothetical protein Antitoxin
SSUJS14_RS04820 972139..974109 - 1971 WP_012775105.1 FtsX-like permease family protein -
SSUJS14_RS04825 974110..974862 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSUJS14_RS04830 974998..975732 - 735 WP_011922410.1 ABC transporter permease -
SSUJS14_RS04835 975734..976480 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T27115 WP_011922404.1 NC_017618:c971812-971555 [Streptococcus suis JS14]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T27115 NC_017618:c971812-971555 [Streptococcus suis JS14]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT27115 WP_012775104.1 NC_017618:c972047-971796 [Streptococcus suis JS14]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT27115 NC_017618:c972047-971796 [Streptococcus suis JS14]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References