Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 720174..720660 Replicon chromosome
Accession NC_017618
Organism Streptococcus suis JS14

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag SSUJS14_RS03635 Protein ID WP_011922754.1
Coordinates 720391..720660 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag SSUJS14_RS03630 Protein ID WP_002938604.1
Coordinates 720174..720401 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUJS14_RS03600 715218..715667 - 450 WP_009909619.1 MarR family transcriptional regulator -
SSUJS14_RS10750 715961..716808 + 848 WP_087892711.1 IS630 family transposase -
SSUJS14_RS03615 716867..717364 + 498 WP_011922751.1 DUF5590 domain-containing protein -
SSUJS14_RS03620 717361..718542 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
SSUJS14_RS03625 718557..719903 + 1347 WP_011922752.1 asparagine--tRNA ligase -
SSUJS14_RS03630 720174..720401 + 228 WP_002938604.1 hypothetical protein Antitoxin
SSUJS14_RS03635 720391..720660 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUJS14_RS03640 721066..722385 + 1320 WP_012775027.1 MATE family efflux transporter -
SSUJS14_RS03645 722436..722813 + 378 WP_002937263.1 RidA family protein -
SSUJS14_RS03650 722835..723722 + 888 WP_011922160.1 RNase adapter RapZ -
SSUJS14_RS03655 723719..724693 + 975 WP_002937257.1 YvcK family protein -
SSUJS14_RS03660 724690..725607 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T27114 WP_011922754.1 NC_017618:720391-720660 [Streptococcus suis JS14]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T27114 NC_017618:720391-720660 [Streptococcus suis JS14]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT27114 WP_002938604.1 NC_017618:720174-720401 [Streptococcus suis JS14]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT27114 NC_017618:720174-720401 [Streptococcus suis JS14]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References