Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4308853..4309634 | Replicon | chromosome |
| Accession | NZ_CP117396 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain RM016 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | PQP86_RS21155 | Protein ID | WP_000626100.1 |
| Coordinates | 4308853..4309344 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | PQP86_RS21160 | Protein ID | WP_001110452.1 |
| Coordinates | 4309341..4309634 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP86_RS21120 (4304848) | 4304848..4305423 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| PQP86_RS21130 (4305694) | 4305694..4305771 | - | 78 | Protein_4131 | helix-turn-helix domain-containing protein | - |
| PQP86_RS21135 (4305862) | 4305862..4306194 | - | 333 | WP_001165472.1 | MerR family transcriptional regulator | - |
| PQP86_RS21140 (4306266) | 4306266..4306643 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| PQP86_RS21145 (4307676) | 4307676..4307750 | + | 75 | Protein_4134 | porin family protein | - |
| PQP86_RS21150 (4307853) | 4307853..4308605 | + | 753 | WP_000842427.1 | non-specific acid phosphatase | - |
| PQP86_RS21155 (4308853) | 4308853..4309344 | - | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| PQP86_RS21160 (4309341) | 4309341..4309634 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP86_RS21165 (4309951) | 4309951..4310172 | + | 222 | WP_001654251.1 | hypothetical protein | - |
| PQP86_RS21170 (4310437) | 4310437..4311312 | + | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| PQP86_RS21175 (4311309) | 4311309..4311596 | + | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| PQP86_RS21180 (4311736) | 4311736..4312110 | + | 375 | WP_230320449.1 | Ig-like domain-containing protein | - |
| PQP86_RS21185 (4312405) | 4312405..4313310 | - | 906 | WP_001268198.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T271133 WP_000626100.1 NZ_CP117396:c4309344-4308853 [Salmonella enterica subsp. enterica serovar Uganda]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT271133 WP_001110452.1 NZ_CP117396:c4309634-4309341 [Salmonella enterica subsp. enterica serovar Uganda]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |