Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486838..3487458 Replicon chromosome
Accession NZ_CP117396
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM016

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP86_RS17285 Protein ID WP_001280991.1
Coordinates 3487240..3487458 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP86_RS17280 Protein ID WP_000344807.1
Coordinates 3486838..3487212 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP86_RS17270 (3481977) 3481977..3483170 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP86_RS17275 (3483193) 3483193..3486342 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP86_RS17280 (3486838) 3486838..3487212 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP86_RS17285 (3487240) 3487240..3487458 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP86_RS17290 (3487637) 3487637..3488188 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQP86_RS17295 (3488306) 3488306..3488776 + 471 WP_000136183.1 YlaC family protein -
PQP86_RS17300 (3488832) 3488832..3488972 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP86_RS17305 (3488978) 3488978..3489238 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP86_RS17310 (3489463) 3489463..3491013 + 1551 WP_076932570.1 EAL domain-containing protein -
PQP86_RS17320 (3491244) 3491244..3491633 + 390 WP_000961285.1 MGMT family protein -
PQP86_RS17325 (3491666) 3491666..3492235 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271125 WP_001280991.1 NZ_CP117396:3487240-3487458 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271125 WP_000344807.1 NZ_CP117396:3486838-3487212 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References