271124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2369439..2369961 Replicon chromosome
Accession NZ_CP117396
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM016

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PQP86_RS11530 Protein ID WP_000221345.1
Coordinates 2369677..2369961 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP86_RS11525 Protein ID WP_000885424.1
Coordinates 2369439..2369687 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP86_RS11500 (2365075) 2365075..2365983 - 909 WP_079798353.1 LysR family transcriptional regulator -
PQP86_RS11505 (2366900) 2366900..2367635 + 736 Protein_2249 helix-turn-helix domain-containing protein -
PQP86_RS11510 (2367691) 2367691..2368599 - 909 WP_079798383.1 hypothetical protein -
PQP86_RS11515 (2368750) 2368750..2369082 - 333 WP_000253155.1 DUF1493 family protein -
PQP86_RS11520 (2369072) 2369072..2369287 - 216 WP_000206206.1 hypothetical protein -
PQP86_RS11525 (2369439) 2369439..2369687 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP86_RS11530 (2369677) 2369677..2369961 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP86_RS11535 (2370121) 2370121..2370510 + 390 WP_001652798.1 RidA family protein -
PQP86_RS11540 (2370562) 2370562..2371641 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP86_RS11545 (2371834) 2371834..2372322 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP86_RS11550 (2372367) 2372367..2373875 + 1509 WP_079798354.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2362203..2376732 14529
- flank IS/Tn - - 2366900..2367469 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T271124 WP_000221345.1 NZ_CP117396:2369677-2369961 [Salmonella enterica subsp. enterica serovar Uganda]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271124 WP_000885424.1 NZ_CP117396:2369439-2369687 [Salmonella enterica subsp. enterica serovar Uganda]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References