Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 188575..189335 | Replicon | chromosome |
| Accession | NZ_CP117396 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain RM016 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | PQP86_RS00880 | Protein ID | WP_000533909.1 |
| Coordinates | 188850..189335 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | PQP86_RS00875 | Protein ID | WP_000965886.1 |
| Coordinates | 188575..188862 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP86_RS00855 (183980) | 183980..184891 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| PQP86_RS00860 (184901) | 184901..186970 | + | 2070 | WP_001291739.1 | glycine--tRNA ligase subunit beta | - |
| PQP86_RS00865 (187360) | 187360..187758 | + | 399 | Protein_171 | IS3 family transposase | - |
| PQP86_RS00870 (187930) | 187930..188397 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| PQP86_RS00875 (188575) | 188575..188862 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP86_RS00880 (188850) | 188850..189335 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| PQP86_RS00885 (189706) | 189706..190245 | - | 540 | WP_000047147.1 | copper-binding periplasmic metallochaperone CueP | - |
| PQP86_RS00890 (190419) | 190419..190631 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| PQP86_RS00895 (190920) | 190920..191210 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| PQP86_RS00900 (191649) | 191649..192359 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| PQP86_RS00905 (192409) | 192409..193383 | - | 975 | WP_000804683.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| PQP86_RS00910 (193602) | 193602..194264 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T271115 WP_000533909.1 NZ_CP117396:188850-189335 [Salmonella enterica subsp. enterica serovar Uganda]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT271115 WP_000965886.1 NZ_CP117396:188575-188862 [Salmonella enterica subsp. enterica serovar Uganda]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |