Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1386486..1386969 Replicon chromosome
Accession NC_017617
Organism Streptococcus suis GZ1

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSGZ1_RS06795 Protein ID WP_012027435.1
Coordinates 1386486..1386746 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSGZ1_RS06800 Protein ID WP_012775256.1
Coordinates 1386748..1386969 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSGZ1_RS06770 1381872..1383101 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSGZ1_RS06775 1383091..1384257 - 1167 WP_041179118.1 AI-2E family transporter -
SSGZ1_RS06780 1384393..1385396 + 1004 Protein_1284 lactonase family protein -
SSGZ1_RS06785 1385460..1385645 + 186 WP_002935693.1 hypothetical protein -
SSGZ1_RS06790 1385678..1386319 - 642 WP_012775255.1 HAD family hydrolase -
SSGZ1_RS06795 1386486..1386746 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSGZ1_RS06800 1386748..1386969 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSGZ1_RS06805 1387279..1388586 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSGZ1_RS06810 1388736..1389188 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSGZ1_RS10300 1389195..1389424 - 230 Protein_1291 hypothetical protein -
SSGZ1_RS06815 1389415..1390542 - 1128 WP_012028382.1 glycerate kinase -
SSGZ1_RS06820 1390650..1391300 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T27111 WP_012027435.1 NC_017617:c1386746-1386486 [Streptococcus suis GZ1]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27111 NC_017617:c1386746-1386486 [Streptococcus suis GZ1]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27111 WP_012775256.1 NC_017617:c1386969-1386748 [Streptococcus suis GZ1]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27111 NC_017617:c1386969-1386748 [Streptococcus suis GZ1]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References