271102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2369324..2369846 Replicon chromosome
Accession NZ_CP117394
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PQP77_RS11535 Protein ID WP_000221345.1
Coordinates 2369562..2369846 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP77_RS11530 Protein ID WP_000885424.1
Coordinates 2369324..2369572 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP77_RS11505 (2364960) 2364960..2365868 - 909 WP_079798353.1 LysR family transcriptional regulator -
PQP77_RS11510 (2366785) 2366785..2367520 + 736 Protein_2250 helix-turn-helix domain-containing protein -
PQP77_RS11515 (2367576) 2367576..2368484 - 909 WP_079798383.1 hypothetical protein -
PQP77_RS11520 (2368635) 2368635..2368967 - 333 WP_000253155.1 DUF1493 family protein -
PQP77_RS11525 (2368957) 2368957..2369172 - 216 WP_000206206.1 hypothetical protein -
PQP77_RS11530 (2369324) 2369324..2369572 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP77_RS11535 (2369562) 2369562..2369846 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP77_RS11540 (2370006) 2370006..2370395 + 390 WP_001652798.1 RidA family protein -
PQP77_RS11545 (2370447) 2370447..2371526 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP77_RS11550 (2371719) 2371719..2372207 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP77_RS11555 (2372252) 2372252..2373760 + 1509 WP_079798354.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2362088..2376617 14529
- flank IS/Tn - - 2366785..2367354 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T271102 WP_000221345.1 NZ_CP117394:2369562-2369846 [Salmonella enterica subsp. enterica serovar Uganda]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271102 WP_000885424.1 NZ_CP117394:2369324-2369572 [Salmonella enterica subsp. enterica serovar Uganda]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References