Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 188567..189327 Replicon chromosome
Accession NZ_CP117394
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQP77_RS00880 Protein ID WP_000533909.1
Coordinates 188842..189327 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQP77_RS00875 Protein ID WP_000965886.1
Coordinates 188567..188854 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP77_RS00855 (183972) 183972..184883 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQP77_RS00860 (184893) 184893..186962 + 2070 WP_001291739.1 glycine--tRNA ligase subunit beta -
PQP77_RS00865 (187352) 187352..187750 + 399 Protein_171 IS3 family transposase -
PQP77_RS00870 (187922) 187922..188389 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQP77_RS00875 (188567) 188567..188854 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQP77_RS00880 (188842) 188842..189327 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQP77_RS00885 (189698) 189698..190237 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
PQP77_RS00890 (190411) 190411..190623 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQP77_RS00895 (190912) 190912..191202 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQP77_RS00900 (191641) 191641..192351 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQP77_RS00905 (192401) 192401..193375 - 975 WP_000804683.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQP77_RS00910 (193594) 193594..194256 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T271093 WP_000533909.1 NZ_CP117394:188842-189327 [Salmonella enterica subsp. enterica serovar Uganda]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT271093 WP_000965886.1 NZ_CP117394:188567-188854 [Salmonella enterica subsp. enterica serovar Uganda]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References