Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4127698..4128479 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V8KWJ7
Locus tag PQQ03_RS20175 Protein ID WP_001609688.1
Coordinates 4127698..4128189 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag PQQ03_RS20180 Protein ID WP_001110453.1
Coordinates 4128186..4128479 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS20150 (4122834) 4122834..4125272 - 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -
PQQ03_RS20155 (4125282) 4125282..4125821 - 540 WP_000721295.1 type 1 fimbrial protein -
PQQ03_RS20160 (4125856) 4125856..4126146 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ03_RS20165 (4126733) 4126733..4126960 + 228 WP_001112992.1 hypothetical protein -
PQQ03_RS20170 (4127235) 4127235..4127483 - 249 Protein_3939 IS481 family transposase -
PQQ03_RS20175 (4127698) 4127698..4128189 - 492 WP_001609688.1 GNAT family N-acetyltransferase Toxin
PQQ03_RS20180 (4128186) 4128186..4128479 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
PQQ03_RS20185 (4128797) 4128797..4129019 + 223 Protein_3942 hypothetical protein -
PQQ03_RS20190 (4129283) 4129283..4130158 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQQ03_RS20195 (4130155) 4130155..4130442 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ03_RS20200 (4130435) 4130435..4130617 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
PQQ03_RS20205 (4130637) 4130637..4130736 + 100 Protein_3946 hypothetical protein -
PQQ03_RS20210 (4130846) 4130846..4130980 + 135 Protein_3947 hypothetical protein -
PQQ03_RS20215 (4131275) 4131275..4132180 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4116077..4130617 14540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17664.46 Da        Isoelectric Point: 7.2655

>T271090 WP_001609688.1 NZ_CP117392:c4128189-4127698 [Salmonella enterica subsp. enterica serovar Give]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVEETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT271090 WP_001110453.1 NZ_CP117392:c4128479-4128186 [Salmonella enterica subsp. enterica serovar Give]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8KWJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References