Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 646968..647454 Replicon chromosome
Accession NC_017617
Organism Streptococcus suis GZ1

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag SSGZ1_RS03230 Protein ID WP_011922754.1
Coordinates 647185..647454 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag SSGZ1_RS03225 Protein ID WP_002938604.1
Coordinates 646968..647195 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSGZ1_RS03195 642012..642461 - 450 WP_014635929.1 MarR family transcriptional regulator -
SSGZ1_RS10160 642755..643602 + 848 WP_087892711.1 IS630 family transposase -
SSGZ1_RS03210 643661..644158 + 498 WP_011922751.1 DUF5590 domain-containing protein -
SSGZ1_RS03215 644155..645336 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
SSGZ1_RS03220 645351..646696 + 1346 Protein_581 asparagine--tRNA ligase -
SSGZ1_RS03225 646968..647195 + 228 WP_002938604.1 hypothetical protein Antitoxin
SSGZ1_RS03230 647185..647454 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSGZ1_RS03235 647860..649179 + 1320 WP_012775027.1 MATE family efflux transporter -
SSGZ1_RS03240 649230..649607 + 378 WP_002937263.1 RidA family protein -
SSGZ1_RS03245 649629..650516 + 888 WP_011922160.1 RNase adapter RapZ -
SSGZ1_RS03250 650513..651487 + 975 WP_002937257.1 YvcK family protein -
SSGZ1_RS03255 651484..652401 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T27109 WP_011922754.1 NC_017617:647185-647454 [Streptococcus suis GZ1]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T27109 NC_017617:647185-647454 [Streptococcus suis GZ1]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT27109 WP_002938604.1 NC_017617:646968-647195 [Streptococcus suis GZ1]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT27109 NC_017617:646968-647195 [Streptococcus suis GZ1]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References