Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3989801..3990317 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name relE Uniprot ID A0A5J2LRU5
Locus tag PQQ03_RS19455 Protein ID WP_001609934.1
Coordinates 3989801..3990085 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ03_RS19460 Protein ID WP_000212724.1
Coordinates 3990075..3990317 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS19440 (3984917) 3984917..3986569 + 1653 WP_023212814.1 alpha,alpha-phosphotrehalase -
PQQ03_RS19445 (3986978) 3986978..3989116 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ03_RS19450 (3989333) 3989333..3989797 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ03_RS19455 (3989801) 3989801..3990085 - 285 WP_001609934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ03_RS19460 (3990075) 3990075..3990317 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ03_RS19465 (3990395) 3990395..3992308 - 1914 WP_001609931.1 BglG family transcription antiterminator -
PQQ03_RS19470 (3992325) 3992325..3993065 - 741 WP_023229489.1 KDGP aldolase family protein -
PQQ03_RS19475 (3993062) 3993062..3994180 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ03_RS19480 (3994164) 3994164..3995297 - 1134 WP_001609909.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10859.66 Da        Isoelectric Point: 9.3941

>T271089 WP_001609934.1 NZ_CP117392:c3990085-3989801 [Salmonella enterica subsp. enterica serovar Give]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271089 WP_000212724.1 NZ_CP117392:c3990317-3990075 [Salmonella enterica subsp. enterica serovar Give]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J2LRU5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References