Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3949183..3949733 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQQ03_RS19255 Protein ID WP_001199743.1
Coordinates 3949183..3949491 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag PQQ03_RS19260 Protein ID WP_000016243.1
Coordinates 3949494..3949733 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS19245 (3944583) 3944583..3948098 - 3516 WP_000342548.1 AAA domain-containing protein -
PQQ03_RS19250 (3948460) 3948460..3948761 - 302 Protein_3760 Arm DNA-binding domain-containing protein -
PQQ03_RS19255 (3949183) 3949183..3949491 - 309 WP_001199743.1 CcdB family protein Toxin
PQQ03_RS19260 (3949494) 3949494..3949733 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQQ03_RS19265 (3949842) 3949842..3950066 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
PQQ03_RS19275 (3950851) 3950851..3951870 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQQ03_RS19280 (3951898) 3951898..3952428 - 531 WP_023231125.1 gluconokinase -
PQQ03_RS19285 (3952645) 3952645..3953676 + 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
PQQ03_RS19290 (3953701) 3953701..3954465 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T271088 WP_001199743.1 NZ_CP117392:c3949491-3949183 [Salmonella enterica subsp. enterica serovar Give]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT271088 WP_000016243.1 NZ_CP117392:c3949733-3949494 [Salmonella enterica subsp. enterica serovar Give]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References