Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3320680..3321300 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ03_RS16345 Protein ID WP_001280991.1
Coordinates 3321082..3321300 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ03_RS16340 Protein ID WP_000344807.1
Coordinates 3320680..3321054 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS16330 (3315819) 3315819..3317012 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ03_RS16335 (3317035) 3317035..3320184 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ03_RS16340 (3320680) 3320680..3321054 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ03_RS16345 (3321082) 3321082..3321300 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ03_RS16350 (3321479) 3321479..3322030 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQQ03_RS16355 (3322148) 3322148..3322618 + 471 WP_000136183.1 YlaC family protein -
PQQ03_RS16360 (3322674) 3322674..3322814 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ03_RS16365 (3322820) 3322820..3323080 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ03_RS16370 (3323305) 3323305..3324855 + 1551 WP_023230872.1 EAL domain-containing protein -
PQQ03_RS16380 (3325086) 3325086..3325475 + 390 WP_023230873.1 MGMT family protein -
PQQ03_RS16385 (3325508) 3325508..3326077 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271087 WP_001280991.1 NZ_CP117392:3321082-3321300 [Salmonella enterica subsp. enterica serovar Give]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271087 WP_000344807.1 NZ_CP117392:3320680-3321054 [Salmonella enterica subsp. enterica serovar Give]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References