Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208867..209627 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag PQQ03_RS00990 Protein ID WP_000533907.1
Coordinates 209142..209627 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQQ03_RS00985 Protein ID WP_000965886.1
Coordinates 208867..209154 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS00960 (203956) 203956..204258 + 303 WP_000605592.1 YsaB family lipoprotein -
PQQ03_RS00965 (204397) 204397..205308 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
PQQ03_RS00970 (205318) 205318..207387 + 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
PQQ03_RS00975 (207649) 207649..208080 + 432 Protein_193 IS3 family transposase -
PQQ03_RS00980 (208222) 208222..208689 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQQ03_RS00985 (208867) 208867..209154 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQQ03_RS00990 (209142) 209142..209627 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
PQQ03_RS00995 (209998) 209998..210537 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
PQQ03_RS01000 (210710) 210710..210922 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQQ03_RS01005 (211210) 211210..211500 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQQ03_RS01010 (211939) 211939..212649 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQQ03_RS01015 (212699) 212699..213673 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQQ03_RS01020 (213903) 213903..214565 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T271080 WP_000533907.1 NZ_CP117392:209142-209627 [Salmonella enterica subsp. enterica serovar Give]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T271080 NZ_CP117392:209142-209627 [Salmonella enterica subsp. enterica serovar Give]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTATCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACTTTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT271080 WP_000965886.1 NZ_CP117392:208867-209154 [Salmonella enterica subsp. enterica serovar Give]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT271080 NZ_CP117392:208867-209154 [Salmonella enterica subsp. enterica serovar Give]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References