Detailed information of TA system TA027108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1579963..1580575
• Replicon: chromosome
• Accession: NC_017596
• Organism: Streptococcus pyogenes Alab49

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SPYALAB49_RS07980
• Protein ID: WP_014635711.1
• Coordinates: 1580240..1580575 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: SPYALAB49_RS07975
• Protein ID: WP_002988079.1
• Coordinates: 1579963..1580250 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPYALAB49_RS07950	1575153..1576136	-	984	WP_014635708.1	tagatose-bisphosphate aldolase	-
SPYALAB49_RS07955	1576140..1577069	-	930	WP_002982751.1	tagatose-6-phosphate kinase	-
SPYALAB49_RS07960	1577117..1577632	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
SPYALAB49_RS07965	1577667..1578095	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
SPYALAB49_RS07970	1578540..1579313	+	774	WP_014635710.1	DeoR/GlpR family DNA-binding transcription regulator	-
SPYALAB49_RS07975	1579963..1580250	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
SPYALAB49_RS07980	1580240..1580575	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPYALAB49_RS09830	1580727..1581197	+	471	WP_021733374.1	site-specific integrase	-
SPYALAB49_RS09835	1581160..1581708	+	549	WP_181879157.1	site-specific integrase	-
SPYALAB49_RS07990	1581828..1582220	-	393	WP_002982716.1	30S ribosomal protein S9	-
SPYALAB49_RS07995	1582241..1582687	-	447	WP_002982710.1	50S ribosomal protein L13	-
SPYALAB49_RS08000	1582905..1583111	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SPYALAB49_RS08005	1583108..1583614	-	507	WP_002988070.1	hypothetical protein	-
SPYALAB49_RS08010	1583750..1584610	-	861	WP_002982687.1	DegV family protein	-
SPYALAB49_RS08015	1584707..1585225	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T27108 WP_014635711.1 NC_017596:1580240-1580575 [Streptococcus pyogenes Alab49]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T27108 NC_017596:1580240-1580575 [Streptococcus pyogenes Alab49]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT27108 WP_002988079.1 NC_017596:1579963-1580250 [Streptococcus pyogenes Alab49]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT27108 NC_017596:1579963-1580250 [Streptococcus pyogenes Alab49]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94