Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4269330..4270111 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag PQP88_RS20850 Protein ID WP_000626100.1
Coordinates 4269330..4269821 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP88_RS20855 Protein ID WP_001110452.1
Coordinates 4269818..4270111 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS20810 (4265326) 4265326..4265901 + 576 WP_001188509.1 transcriptional regulator -
PQP88_RS20820 (4266172) 4266172..4266249 - 78 Protein_4071 helix-turn-helix domain-containing protein -
PQP88_RS20825 (4266340) 4266340..4266672 - 333 WP_001165472.1 MerR family transcriptional regulator -
PQP88_RS20830 (4266744) 4266744..4267022 + 279 WP_274890460.1 EthD domain-containing protein -
PQP88_RS20835 (4266965) 4266965..4267120 + 156 WP_274890461.1 hypothetical protein -
PQP88_RS20840 (4268153) 4268153..4268227 + 75 Protein_4075 porin family protein -
PQP88_RS20845 (4268330) 4268330..4269082 + 753 WP_000842427.1 non-specific acid phosphatase -
PQP88_RS20850 (4269330) 4269330..4269821 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
PQP88_RS20855 (4269818) 4269818..4270111 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP88_RS20860 (4270428) 4270428..4270649 + 222 WP_001654251.1 hypothetical protein -
PQP88_RS20865 (4270914) 4270914..4271789 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQP88_RS20870 (4271786) 4271786..4272073 + 288 WP_001541332.1 transcriptional regulator RtsB -
PQP88_RS20875 (4272213) 4272213..4272587 + 375 WP_230320449.1 Ig-like domain-containing protein -
PQP88_RS20880 (4272882) 4272882..4273787 - 906 WP_001268198.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T271076 WP_000626100.1 NZ_CP117390:c4269821-4269330 [Salmonella enterica subsp. enterica serovar Uganda]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT271076 WP_001110452.1 NZ_CP117390:c4270111-4269818 [Salmonella enterica subsp. enterica serovar Uganda]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References