Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4163701..4164217 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag PQP88_RS20270 Protein ID WP_000220577.1
Coordinates 4163701..4163985 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP88_RS20275 Protein ID WP_000212724.1
Coordinates 4163975..4164217 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS20255 (4158817) 4158817..4160469 + 1653 WP_079798427.1 alpha,alpha-phosphotrehalase -
PQP88_RS20260 (4160878) 4160878..4163016 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQP88_RS20265 (4163233) 4163233..4163697 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP88_RS20270 (4163701) 4163701..4163985 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP88_RS20275 (4163975) 4163975..4164217 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP88_RS20280 (4164295) 4164295..4166208 - 1914 WP_001212131.1 BglG family transcription antiterminator -
PQP88_RS20285 (4166225) 4166225..4166965 - 741 WP_000779252.1 KDGP aldolase family protein -
PQP88_RS20290 (4166962) 4166962..4168080 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP88_RS20295 (4168064) 4168064..4169197 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T271075 WP_000220577.1 NZ_CP117390:c4163985-4163701 [Salmonella enterica subsp. enterica serovar Uganda]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271075 WP_000212724.1 NZ_CP117390:c4164217-4163975 [Salmonella enterica subsp. enterica serovar Uganda]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References