Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3447329..3447949 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP88_RS16970 Protein ID WP_001280991.1
Coordinates 3447731..3447949 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP88_RS16965 Protein ID WP_000344807.1
Coordinates 3447329..3447703 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS16955 (3442468) 3442468..3443661 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP88_RS16960 (3443684) 3443684..3446833 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP88_RS16965 (3447329) 3447329..3447703 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP88_RS16970 (3447731) 3447731..3447949 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP88_RS16975 (3448128) 3448128..3448679 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQP88_RS16980 (3448797) 3448797..3449267 + 471 WP_000136183.1 YlaC family protein -
PQP88_RS16985 (3449323) 3449323..3449463 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP88_RS16990 (3449469) 3449469..3449729 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP88_RS16995 (3449954) 3449954..3451504 + 1551 WP_076932570.1 EAL domain-containing protein -
PQP88_RS17005 (3451735) 3451735..3452124 + 390 WP_000961285.1 MGMT family protein -
PQP88_RS17010 (3452157) 3452157..3452726 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271068 WP_001280991.1 NZ_CP117390:3447731-3447949 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271068 WP_000344807.1 NZ_CP117390:3447329-3447703 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References