Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849182..849807 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQP88_RS04175 Protein ID WP_274890525.1
Coordinates 849409..849807 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PQP88_RS04170 Protein ID WP_000557545.1
Coordinates 849182..849409 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS04140 (844278) 844278..845376 + 1099 WP_010989230.1 peptide chain release factor 2 -
PQP88_RS04145 (845386) 845386..846903 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP88_RS04150 (846979) 846979..847524 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
PQP88_RS04155 (847789) 847789..848547 + 759 WP_000244328.1 amidase activator ActS -
PQP88_RS04165 (848793) 848793..849005 - 213 WP_024152440.1 hypothetical protein -
PQP88_RS04170 (849182) 849182..849409 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP88_RS04175 (849409) 849409..849807 + 399 WP_274890525.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP88_RS04180 (850616) 850616..851152 + 537 WP_001038503.1 STM3031 family outer membrane protein -
PQP88_RS04185 (851199) 851199..851831 + 633 WP_000835265.1 YfdX family protein -
PQP88_RS04190 (852550) 852550..853137 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 848793..858955 10162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15038.38 Da        Isoelectric Point: 8.2817

>T271060 WP_274890525.1 NZ_CP117390:849409-849807 [Salmonella enterica subsp. enterica serovar Uganda]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSRAPERNLAGVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT271060 WP_000557545.1 NZ_CP117390:849182-849409 [Salmonella enterica subsp. enterica serovar Uganda]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References