Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4308876..4309657 | Replicon | chromosome |
| Accession | NZ_CP117388 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain RM010 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | PQQ04_RS21165 | Protein ID | WP_000626100.1 |
| Coordinates | 4308876..4309367 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | PQQ04_RS21170 | Protein ID | WP_001110452.1 |
| Coordinates | 4309364..4309657 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQQ04_RS21130 (4304871) | 4304871..4305446 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| PQQ04_RS21140 (4305717) | 4305717..4305794 | - | 78 | Protein_4133 | helix-turn-helix domain-containing protein | - |
| PQQ04_RS21145 (4305885) | 4305885..4306217 | - | 333 | WP_001165472.1 | MerR family transcriptional regulator | - |
| PQQ04_RS21150 (4306289) | 4306289..4306666 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| PQQ04_RS21155 (4307699) | 4307699..4307773 | + | 75 | Protein_4136 | porin family protein | - |
| PQQ04_RS21160 (4307876) | 4307876..4308628 | + | 753 | WP_000842427.1 | non-specific acid phosphatase | - |
| PQQ04_RS21165 (4308876) | 4308876..4309367 | - | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| PQQ04_RS21170 (4309364) | 4309364..4309657 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| PQQ04_RS21175 (4309974) | 4309974..4310195 | + | 222 | WP_001654251.1 | hypothetical protein | - |
| PQQ04_RS21180 (4310460) | 4310460..4311335 | + | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| PQQ04_RS21185 (4311332) | 4311332..4311619 | + | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| PQQ04_RS21190 (4311759) | 4311759..4312133 | + | 375 | WP_230320449.1 | Ig-like domain-containing protein | - |
| PQQ04_RS21195 (4312428) | 4312428..4313333 | - | 906 | WP_001268198.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T271054 WP_000626100.1 NZ_CP117388:c4309367-4308876 [Salmonella enterica subsp. enterica serovar Uganda]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT271054 WP_001110452.1 NZ_CP117388:c4309657-4309364 [Salmonella enterica subsp. enterica serovar Uganda]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |