Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4203245..4203761 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag PQQ04_RS20590 Protein ID WP_000220577.1
Coordinates 4203245..4203529 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ04_RS20595 Protein ID WP_000212724.1
Coordinates 4203519..4203761 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ04_RS20575 (4198361) 4198361..4200013 + 1653 WP_079798427.1 alpha,alpha-phosphotrehalase -
PQQ04_RS20580 (4200422) 4200422..4202560 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ04_RS20585 (4202777) 4202777..4203241 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ04_RS20590 (4203245) 4203245..4203529 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ04_RS20595 (4203519) 4203519..4203761 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ04_RS20600 (4203839) 4203839..4205752 - 1914 WP_274894932.1 BglG family transcription antiterminator -
PQQ04_RS20605 (4205769) 4205769..4206509 - 741 WP_000779252.1 KDGP aldolase family protein -
PQQ04_RS20610 (4206506) 4206506..4207624 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ04_RS20615 (4207608) 4207608..4208741 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T271053 WP_000220577.1 NZ_CP117388:c4203529-4203245 [Salmonella enterica subsp. enterica serovar Uganda]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271053 WP_000212724.1 NZ_CP117388:c4203761-4203519 [Salmonella enterica subsp. enterica serovar Uganda]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References