Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486881..3487501 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ04_RS17290 Protein ID WP_001280991.1
Coordinates 3487283..3487501 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ04_RS17285 Protein ID WP_000344807.1
Coordinates 3486881..3487255 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ04_RS17275 (3482020) 3482020..3483213 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ04_RS17280 (3483236) 3483236..3486385 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ04_RS17285 (3486881) 3486881..3487255 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ04_RS17290 (3487283) 3487283..3487501 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ04_RS17295 (3487680) 3487680..3488231 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQQ04_RS17300 (3488349) 3488349..3488819 + 471 WP_000136183.1 YlaC family protein -
PQQ04_RS17305 (3488875) 3488875..3489015 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ04_RS17310 (3489021) 3489021..3489281 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ04_RS17315 (3489506) 3489506..3491056 + 1551 WP_076932570.1 EAL domain-containing protein -
PQQ04_RS17325 (3491287) 3491287..3491676 + 390 WP_000961285.1 MGMT family protein -
PQQ04_RS17330 (3491709) 3491709..3492278 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271046 WP_001280991.1 NZ_CP117388:3487283-3487501 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271046 WP_000344807.1 NZ_CP117388:3486881-3487255 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References