Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 795179..795638 Replicon chromosome
Accession NC_017594
Organism Streptococcus salivarius 57 I

Toxin (Protein)


Gene name relE Uniprot ID F8HC67
Locus tag SSAL_RS03505 Protein ID WP_014632928.1
Coordinates 795384..795638 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8HC66
Locus tag SSAL_RS03500 Protein ID WP_014632927.1
Coordinates 795179..795394 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSAL_RS03490 (Ssal_00779) 792943..794109 + 1167 WP_014632925.1 hypothetical protein -
SSAL_RS03495 (Ssal_00780) 794203..795045 + 843 WP_014632926.1 aldo/keto reductase -
SSAL_RS03500 (Ssal_00781) 795179..795394 + 216 WP_014632927.1 DUF6290 family protein Antitoxin
SSAL_RS03505 (Ssal_00782) 795384..795638 + 255 WP_014632928.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSAL_RS03510 (Ssal_00783) 795783..796469 + 687 WP_004182263.1 YoaK family protein -
SSAL_RS03515 (Ssal_00784) 796560..797192 + 633 WP_014632930.1 nitroreductase family protein -
SSAL_RS03520 (Ssal_00785) 797356..798039 + 684 WP_014632931.1 response regulator transcription factor -
SSAL_RS03525 (Ssal_00786) 798039..798914 + 876 WP_014632932.1 HAMP domain-containing sensor histidine kinase -
SSAL_RS03530 (Ssal_00787) 799199..799708 + 510 WP_014632933.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9887.66 Da        Isoelectric Point: 11.1183

>T27104 WP_014632928.1 NC_017594:795384-795638 [Streptococcus salivarius 57.I]
MTYKIVPTPKFAKNFKKLDPFVRKQIKAYLNRVTENPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T27104 NC_017594:795384-795638 [Streptococcus salivarius 57.I]
ATGACCTATAAGATAGTACCCACCCCTAAATTTGCCAAAAATTTTAAAAAGTTAGATCCTTTCGTCAGAAAACAAATTAA
GGCTTATCTCAATCGCGTGACAGAGAATCCAAGAGCCAAGGGTAAGGCCTTGGTTGCCAATCGGACTGGCCAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCTTTAGAAGTCGGTCATAGA
CGTGATATCTATTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8031.00 Da        Isoelectric Point: 3.8964

>AT27104 WP_014632927.1 NC_017594:795179-795394 [Streptococcus salivarius 57.I]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLEAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT27104 NC_017594:795179-795394 [Streptococcus salivarius 57.I]
ATGACAACAATTACATTGAAGGTTTCAGAGGCAGATAAGAAGTTCATGCAGGCCATTGCGAAATTCGAAGGCGTATCCTT
GTCAGAATTAATTCGGACCAAAACTTTAGAAGCCATTGAGGATGAATACGATGCTAGAGTAGCCGATTTGGCTTTGGCAG
AATATGAAGATTATCTAGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8HC67

Antitoxin

Source ID Structure
AlphaFold DB F8HC66

References