Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849062..849687 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQQ04_RS04175 Protein ID WP_000911337.1
Coordinates 849289..849687 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PQQ04_RS04170 Protein ID WP_000557545.1
Coordinates 849062..849289 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ04_RS04140 (844158) 844158..845256 + 1099 WP_010989230.1 peptide chain release factor 2 -
PQQ04_RS04145 (845266) 845266..846783 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQQ04_RS04150 (846859) 846859..847404 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
PQQ04_RS04155 (847669) 847669..848427 + 759 WP_000244328.1 amidase activator ActS -
PQQ04_RS04165 (848673) 848673..848885 - 213 WP_024152440.1 hypothetical protein -
PQQ04_RS04170 (849062) 849062..849289 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQQ04_RS04175 (849289) 849289..849687 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQQ04_RS04180 (850496) 850496..851032 + 537 WP_001038503.1 STM3031 family outer membrane protein -
PQQ04_RS04185 (851079) 851079..851711 + 633 WP_000835265.1 YfdX family protein -
PQQ04_RS04190 (852430) 852430..853017 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 849062..858835 9773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T271038 WP_000911337.1 NZ_CP117388:849289-849687 [Salmonella enterica subsp. enterica serovar Uganda]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT271038 WP_000557545.1 NZ_CP117388:849062-849289 [Salmonella enterica subsp. enterica serovar Uganda]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References