Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4308394..4309175 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag PQP90_RS21175 Protein ID WP_000626100.1
Coordinates 4308394..4308885 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP90_RS21180 Protein ID WP_001110452.1
Coordinates 4308882..4309175 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS21140 (4304389) 4304389..4304964 + 576 WP_001188509.1 transcriptional regulator -
PQP90_RS21150 (4305235) 4305235..4305312 - 78 Protein_4135 helix-turn-helix domain-containing protein -
PQP90_RS21155 (4305403) 4305403..4305735 - 333 WP_001165472.1 MerR family transcriptional regulator -
PQP90_RS21160 (4305807) 4305807..4306184 + 378 WP_000916345.1 EthD family reductase -
PQP90_RS21165 (4307217) 4307217..4307291 + 75 Protein_4138 porin family protein -
PQP90_RS21170 (4307394) 4307394..4308146 + 753 WP_000842427.1 non-specific acid phosphatase -
PQP90_RS21175 (4308394) 4308394..4308885 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
PQP90_RS21180 (4308882) 4308882..4309175 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP90_RS21185 (4309492) 4309492..4309713 + 222 WP_001654251.1 hypothetical protein -
PQP90_RS21190 (4309978) 4309978..4310853 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQP90_RS21195 (4310850) 4310850..4311137 + 288 WP_001541332.1 transcriptional regulator RtsB -
PQP90_RS21200 (4311277) 4311277..4311651 + 375 WP_230320449.1 Ig-like domain-containing protein -
PQP90_RS21205 (4311946) 4311946..4312851 - 906 WP_001268198.1 YjiK family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(85-145)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T271032 WP_000626100.1 NZ_CP117386:c4308885-4308394 [Salmonella enterica subsp. enterica serovar Uganda]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT271032 WP_001110452.1 NZ_CP117386:c4309175-4308882 [Salmonella enterica subsp. enterica serovar Uganda]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IQ80


Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References