Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486392..3487012 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP90_RS17300 Protein ID WP_001280991.1
Coordinates 3486794..3487012 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP90_RS17295 Protein ID WP_000344807.1
Coordinates 3486392..3486766 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS17285 (3481531) 3481531..3482724 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP90_RS17290 (3482747) 3482747..3485896 + 3150 WP_274897632.1 efflux RND transporter permease AcrB -
PQP90_RS17295 (3486392) 3486392..3486766 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP90_RS17300 (3486794) 3486794..3487012 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP90_RS17305 (3487191) 3487191..3487742 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQP90_RS17310 (3487860) 3487860..3488330 + 471 WP_000136183.1 YlaC family protein -
PQP90_RS17315 (3488386) 3488386..3488526 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP90_RS17320 (3488532) 3488532..3488792 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP90_RS17325 (3489017) 3489017..3490567 + 1551 WP_076932570.1 EAL domain-containing protein -
PQP90_RS17335 (3490798) 3490798..3491187 + 390 WP_000961285.1 MGMT family protein -
PQP90_RS17340 (3491220) 3491220..3491789 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271024 WP_001280991.1 NZ_CP117386:3486794-3487012 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271024 WP_000344807.1 NZ_CP117386:3486392-3486766 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References