27102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1639858..1640526 Replicon chromosome
Accession NC_017593
Organism Streptococcus pneumoniae INV200

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPNINV200_RS08560 Protein ID WP_001132285.1
Coordinates 1640347..1640526 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPNINV200_RS08555 Protein ID WP_000961810.1
Coordinates 1639858..1640310 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPNINV200_RS08535 1636707..1637741 - 1035 WP_000747915.1 ATP-binding protein -
SPNINV200_RS08540 1637851..1638009 - 159 WP_000401986.1 7,8-dihydro-8-oxoguanine-triphosphatase -
SPNINV200_RS08545 1638011..1639078 - 1068 WP_000719723.1 M50 family metallopeptidase -
SPNINV200_RS08550 1639097..1639567 - 471 WP_000257084.1 DUF3013 family protein -
SPNINV200_RS08555 1639858..1640310 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPNINV200_RS08560 1640347..1640526 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPNINV200_RS08565 1640663..1640842 - 180 WP_001048906.1 hypothetical protein -
SPNINV200_RS08570 1641007..1641246 - 240 WP_000818078.1 hypothetical protein -
SPNINV200_RS08575 1641516..1642787 + 1272 WP_001113218.1 replication-associated recombination protein A -
SPNINV200_RS08585 1643334..1644653 - 1320 WP_000502558.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T27102 WP_001132285.1 NC_017593:c1640526-1640347 [Streptococcus pneumoniae INV200]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T27102 NC_017593:c1640526-1640347 [Streptococcus pneumoniae INV200]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT27102 WP_000961810.1 NC_017593:c1640310-1639858 [Streptococcus pneumoniae INV200]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT27102 NC_017593:c1640310-1639858 [Streptococcus pneumoniae INV200]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References