271018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2123275..2123797 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PQP90_RS10360 Protein ID WP_000221345.1
Coordinates 2123275..2123559 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP90_RS10365 Protein ID WP_000885424.1
Coordinates 2123549..2123797 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS10340 (2119361) 2119361..2120869 - 1509 WP_079798354.1 FAD-dependent oxidoreductase -
PQP90_RS10345 (2120914) 2120914..2121402 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP90_RS10350 (2121595) 2121595..2122674 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP90_RS10355 (2122726) 2122726..2123115 - 390 WP_001652798.1 RidA family protein -
PQP90_RS10360 (2123275) 2123275..2123559 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP90_RS10365 (2123549) 2123549..2123797 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP90_RS10370 (2123949) 2123949..2124164 + 216 WP_000206206.1 hypothetical protein -
PQP90_RS10375 (2124154) 2124154..2124486 + 333 WP_000253155.1 DUF1493 family protein -
PQP90_RS10380 (2124637) 2124637..2125545 + 909 WP_079798383.1 hypothetical protein -
PQP90_RS10385 (2125601) 2125601..2126336 - 736 Protein_2031 helix-turn-helix domain-containing protein -
PQP90_RS10390 (2127253) 2127253..2128161 + 909 WP_079798353.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2121595..2131033 9438
- flank IS/Tn - - 2125767..2126336 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T271018 WP_000221345.1 NZ_CP117386:c2123559-2123275 [Salmonella enterica subsp. enterica serovar Uganda]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271018 WP_000885424.1 NZ_CP117386:c2123797-2123549 [Salmonella enterica subsp. enterica serovar Uganda]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References