Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3487042..3487662 Replicon chromosome
Accession NZ_CP117384
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM013

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP89_RS17285 Protein ID WP_001280991.1
Coordinates 3487444..3487662 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP89_RS17280 Protein ID WP_000344807.1
Coordinates 3487042..3487416 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP89_RS17270 (3482181) 3482181..3483374 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP89_RS17275 (3483397) 3483397..3486546 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP89_RS17280 (3487042) 3487042..3487416 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP89_RS17285 (3487444) 3487444..3487662 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP89_RS17290 (3487841) 3487841..3488392 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQP89_RS17295 (3488510) 3488510..3488980 + 471 WP_000136183.1 YlaC family protein -
PQP89_RS17300 (3489036) 3489036..3489176 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP89_RS17305 (3489182) 3489182..3489442 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP89_RS17310 (3489667) 3489667..3491217 + 1551 WP_076932570.1 EAL domain-containing protein -
PQP89_RS17320 (3491448) 3491448..3491837 + 390 WP_000961285.1 MGMT family protein -
PQP89_RS17325 (3491870) 3491870..3492439 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271002 WP_001280991.1 NZ_CP117384:3487444-3487662 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271002 WP_000344807.1 NZ_CP117384:3487042-3487416 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References