271001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2369579..2370101 Replicon chromosome
Accession NZ_CP117384
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM013

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PQP89_RS11530 Protein ID WP_000221345.1
Coordinates 2369817..2370101 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP89_RS11525 Protein ID WP_000885424.1
Coordinates 2369579..2369827 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP89_RS11500 (2365215) 2365215..2366123 - 909 WP_079798353.1 LysR family transcriptional regulator -
PQP89_RS11505 (2367040) 2367040..2367775 + 736 Protein_2249 helix-turn-helix domain-containing protein -
PQP89_RS11510 (2367831) 2367831..2368739 - 909 WP_079798383.1 hypothetical protein -
PQP89_RS11515 (2368890) 2368890..2369222 - 333 WP_000253155.1 DUF1493 family protein -
PQP89_RS11520 (2369212) 2369212..2369427 - 216 WP_000206206.1 hypothetical protein -
PQP89_RS11525 (2369579) 2369579..2369827 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP89_RS11530 (2369817) 2369817..2370101 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP89_RS11535 (2370261) 2370261..2370650 + 390 WP_001652798.1 RidA family protein -
PQP89_RS11540 (2370702) 2370702..2371781 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP89_RS11545 (2371974) 2371974..2372462 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP89_RS11550 (2372507) 2372507..2374015 + 1509 WP_079798354.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2362343..2376872 14529
- flank IS/Tn - - 2367040..2367609 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T271001 WP_000221345.1 NZ_CP117384:2369817-2370101 [Salmonella enterica subsp. enterica serovar Uganda]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271001 WP_000885424.1 NZ_CP117384:2369579-2369827 [Salmonella enterica subsp. enterica serovar Uganda]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References