Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4308667..4309448 | Replicon | chromosome |
| Accession | NZ_CP117382 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain RM018 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | PQP98_RS21155 | Protein ID | WP_000626100.1 |
| Coordinates | 4308667..4309158 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | PQP98_RS21160 | Protein ID | WP_001110452.1 |
| Coordinates | 4309155..4309448 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP98_RS21120 (4304662) | 4304662..4305237 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| PQP98_RS21130 (4305508) | 4305508..4305585 | - | 78 | Protein_4131 | helix-turn-helix domain-containing protein | - |
| PQP98_RS21135 (4305676) | 4305676..4306008 | - | 333 | WP_001165472.1 | MerR family transcriptional regulator | - |
| PQP98_RS21140 (4306080) | 4306080..4306457 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| PQP98_RS21145 (4307490) | 4307490..4307564 | + | 75 | Protein_4134 | porin family protein | - |
| PQP98_RS21150 (4307667) | 4307667..4308419 | + | 753 | WP_000842427.1 | non-specific acid phosphatase | - |
| PQP98_RS21155 (4308667) | 4308667..4309158 | - | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| PQP98_RS21160 (4309155) | 4309155..4309448 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| PQP98_RS21165 (4309765) | 4309765..4309986 | + | 222 | WP_001654251.1 | hypothetical protein | - |
| PQP98_RS21170 (4310251) | 4310251..4311126 | + | 876 | Protein_4139 | AraC family transcriptional regulator | - |
| PQP98_RS21175 (4311123) | 4311123..4311410 | + | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| PQP98_RS21180 (4311550) | 4311550..4311924 | + | 375 | WP_230320449.1 | Ig-like domain-containing protein | - |
| PQP98_RS21185 (4312219) | 4312219..4313124 | - | 906 | WP_001268198.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T270988 WP_000626100.1 NZ_CP117382:c4309158-4308667 [Salmonella enterica subsp. enterica serovar Uganda]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT270988 WP_001110452.1 NZ_CP117382:c4309448-4309155 [Salmonella enterica subsp. enterica serovar Uganda]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |