Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486661..3487281 Replicon chromosome
Accession NZ_CP117382
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM018

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP98_RS17275 Protein ID WP_001280991.1
Coordinates 3487063..3487281 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP98_RS17270 Protein ID WP_000344807.1
Coordinates 3486661..3487035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP98_RS17260 (3481800) 3481800..3482993 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP98_RS17265 (3483016) 3483016..3486165 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP98_RS17270 (3486661) 3486661..3487035 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP98_RS17275 (3487063) 3487063..3487281 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP98_RS17280 (3487460) 3487460..3488011 + 552 WP_001278791.1 maltose O-acetyltransferase -
PQP98_RS17285 (3488129) 3488129..3488599 + 471 WP_000136183.1 YlaC family protein -
PQP98_RS17290 (3488655) 3488655..3488795 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP98_RS17295 (3488801) 3488801..3489061 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP98_RS17300 (3489286) 3489286..3490836 + 1551 WP_076932570.1 EAL domain-containing protein -
PQP98_RS17310 (3491067) 3491067..3491456 + 390 WP_000961285.1 MGMT family protein -
PQP98_RS17315 (3491489) 3491489..3492058 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270980 WP_001280991.1 NZ_CP117382:3487063-3487281 [Salmonella enterica subsp. enterica serovar Uganda]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T270980 NZ_CP117382:3487063-3487281 [Salmonella enterica subsp. enterica serovar Uganda]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270980 WP_000344807.1 NZ_CP117382:3486661-3487035 [Salmonella enterica subsp. enterica serovar Uganda]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT270980 NZ_CP117382:3486661-3487035 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAAC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References