Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1582623..1583291 Replicon chromosome
Accession NC_017592
Organism Streptococcus pneumoniae OXC141

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SPNOXC_RS08435 Protein ID WP_001132285.1
Coordinates 1583112..1583291 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag SPNOXC_RS08430 Protein ID WP_000961812.1
Coordinates 1582623..1583075 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPNOXC_RS08405 1578513..1579256 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPNOXC_RS08410 1579258..1580208 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
SPNOXC_RS08415 1580346..1580774 - 429 WP_000418157.1 NUDIX hydrolase -
SPNOXC_RS08420 1580755..1581843 - 1089 WP_000719712.1 M50 family metallopeptidase -
SPNOXC_RS08425 1581862..1582332 - 471 WP_000257088.1 DUF3013 family protein -
SPNOXC_RS08430 1582623..1583075 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPNOXC_RS08435 1583112..1583291 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SPNOXC_RS08440 1583428..1583676 - 249 WP_000797237.1 hypothetical protein -
SPNOXC_RS08445 1583666..1583905 - 240 WP_000818079.1 hypothetical protein -
SPNOXC_RS08450 1584175..1585446 + 1272 WP_001113213.1 replication-associated recombination protein A -
SPNOXC_RS08460 1585866..1586993 - 1128 WP_000323403.1 site-specific integrase -
SPNOXC_RS08465 1586995..1587177 - 183 WP_000655518.1 DUF3173 domain-containing protein -
SPNOXC_RS08470 1587193..1588236 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T27098 WP_001132285.1 NC_017592:c1583291-1583112 [Streptococcus pneumoniae OXC141]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T27098 NC_017592:c1583291-1583112 [Streptococcus pneumoniae OXC141]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT27098 WP_000961812.1 NC_017592:c1583075-1582623 [Streptococcus pneumoniae OXC141]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT27098 NC_017592:c1583075-1582623 [Streptococcus pneumoniae OXC141]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGCTAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References