Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839230..839890 Replicon chromosome
Accession NZ_CP117382
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM018

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag PQP98_RS04110 Protein ID WP_000244761.1
Coordinates 839477..839890 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP98_RS04105 Protein ID WP_000351186.1
Coordinates 839230..839496 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP98_RS04085 (835158) 835158..836591 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
PQP98_RS04090 (836750) 836750..837061 + 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
PQP98_RS04095 (837225) 837225..837884 + 660 WP_000250289.1 hemolysin III family protein -
PQP98_RS04100 (838000) 838000..838980 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PQP98_RS04105 (839230) 839230..839496 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP98_RS04110 (839477) 839477..839890 + 414 WP_000244761.1 protein YgfX Toxin
PQP98_RS04115 (839943) 839943..840464 - 522 WP_001055885.1 flavodoxin FldB -
PQP98_RS04120 (840577) 840577..841473 + 897 WP_000434299.1 site-specific tyrosine recombinase XerD -
PQP98_RS04125 (841497) 841497..842210 + 714 WP_000745615.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP98_RS04130 (842216) 842216..843949 + 1734 WP_274877755.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T270971 WP_000244761.1 NZ_CP117382:839477-839890 [Salmonella enterica subsp. enterica serovar Uganda]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270971 WP_000351186.1 NZ_CP117382:839230-839496 [Salmonella enterica subsp. enterica serovar Uganda]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References