Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4299769..4300550 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP93_RS21110 Protein ID WP_000625912.1
Coordinates 4299769..4300260 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP93_RS21115 Protein ID WP_001110450.1
Coordinates 4300257..4300550 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS21080 (4296030) 4296030..4296527 - 498 WP_001670425.1 FimD/PapC N-terminal domain-containing protein -
PQP93_RS21085 (4296651) 4296651..4297481 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
PQP93_RS21090 (4297683) 4297683..4297988 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP93_RS21095 (4298519) 4298519..4298662 + 144 Protein_4124 transposase -
PQP93_RS21100 (4298679) 4298679..4299025 + 347 Protein_4125 Rpn family recombination-promoting nuclease/putative transposase -
PQP93_RS21105 (4299306) 4299306..4299554 - 249 Protein_4126 IS481 family transposase -
PQP93_RS21110 (4299769) 4299769..4300260 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP93_RS21115 (4300257) 4300257..4300550 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP93_RS21120 (4300867) 4300867..4301089 + 223 Protein_4129 hypothetical protein -
PQP93_RS21125 (4301353) 4301353..4302228 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQP93_RS21130 (4302225) 4302225..4302512 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP93_RS21135 (4302505) 4302505..4302687 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
PQP93_RS21140 (4302707) 4302707..4302806 + 100 Protein_4133 hypothetical protein -
PQP93_RS21145 (4302804) 4302804..4303049 + 246 Protein_4134 hypothetical protein -
PQP93_RS21150 (4303343) 4303343..4304248 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4292858..4302512 9654


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270967 WP_000625912.1 NZ_CP117380:c4300260-4299769 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270967 WP_001110450.1 NZ_CP117380:c4300550-4300257 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References