Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3492775..3493395 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP93_RS17290 Protein ID WP_001280991.1
Coordinates 3493177..3493395 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP93_RS17285 Protein ID WP_000344807.1
Coordinates 3492775..3493149 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS17275 (3487914) 3487914..3489107 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP93_RS17280 (3489130) 3489130..3492279 + 3150 WP_274890115.1 efflux RND transporter permease AcrB -
PQP93_RS17285 (3492775) 3492775..3493149 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP93_RS17290 (3493177) 3493177..3493395 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP93_RS17295 (3493574) 3493574..3494125 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP93_RS17300 (3494242) 3494242..3494712 + 471 WP_000136181.1 YlaC family protein -
PQP93_RS17305 (3494768) 3494768..3494908 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP93_RS17310 (3494914) 3494914..3495174 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP93_RS17315 (3495399) 3495399..3496949 + 1551 WP_274890116.1 EAL domain-containing protein -
PQP93_RS17325 (3497180) 3497180..3497569 + 390 WP_000961287.1 MGMT family protein -
PQP93_RS17330 (3497602) 3497602..3498171 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270963 WP_001280991.1 NZ_CP117380:3493177-3493395 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270963 WP_000344807.1 NZ_CP117380:3492775-3493149 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References