Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 836278..836903 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQP93_RS04040 Protein ID WP_000911337.1
Coordinates 836505..836903 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag PQP93_RS04035 Protein ID WP_000557545.1
Coordinates 836278..836505 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS04005 (831323) 831323..832840 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP93_RS04010 (832916) 832916..833461 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
PQP93_RS04015 (833726) 833726..834484 + 759 WP_000244328.1 amidase activator ActS -
PQP93_RS04025 (834769) 834769..835575 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQP93_RS04030 (835850) 835850..836101 - 252 WP_001540858.1 hypothetical protein -
PQP93_RS04035 (836278) 836278..836505 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP93_RS04040 (836505) 836505..836903 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP93_RS04045 (837711) 837711..838247 + 537 WP_001038502.1 STM3031 family outer membrane protein -
PQP93_RS04050 (838294) 838294..838926 + 633 WP_000835265.1 YfdX family protein -
PQP93_RS04055 (839645) 839645..840226 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 835850..844689 8839


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T270957 WP_000911337.1 NZ_CP117380:836505-836903 [Salmonella enterica subsp. enterica serovar Newport]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT270957 WP_000557545.1 NZ_CP117380:836278-836505 [Salmonella enterica subsp. enterica serovar Newport]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References