Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825391..826051 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP93_RS03975 Protein ID WP_000244756.1
Coordinates 825638..826051 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP93_RS03970 Protein ID WP_000351186.1
Coordinates 825391..825657 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS03950 (821323) 821323..822756 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQP93_RS03955 (822911) 822911..823225 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQP93_RS03960 (823386) 823386..824045 + 660 WP_000250289.1 hemolysin III family protein -
PQP93_RS03965 (824161) 824161..825141 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PQP93_RS03970 (825391) 825391..825657 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP93_RS03975 (825638) 825638..826051 + 414 WP_000244756.1 protein YgfX Toxin
PQP93_RS03980 (826104) 826104..826625 - 522 WP_001055885.1 flavodoxin FldB -
PQP93_RS03985 (826738) 826738..827634 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP93_RS03990 (827658) 827658..828371 + 714 WP_000745621.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP93_RS03995 (828377) 828377..830110 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270956 WP_000244756.1 NZ_CP117380:825638-826051 [Salmonella enterica subsp. enterica serovar Newport]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270956 WP_000351186.1 NZ_CP117380:825391-825657 [Salmonella enterica subsp. enterica serovar Newport]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References