Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1677708..1678376 Replicon chromosome
Accession NC_017591
Organism Streptococcus pneumoniae INV104

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag INV104_RS08785 Protein ID WP_001132276.1
Coordinates 1678197..1678376 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag INV104_RS08780 Protein ID WP_000961810.1
Coordinates 1677708..1678160 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INV104_RS08755 1673598..1674341 - 744 WP_001188229.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
INV104_RS08760 1674343..1675293 - 951 WP_000451130.1 50S ribosomal protein L11 methyltransferase -
INV104_RS08765 1675431..1675859 - 429 WP_000418168.1 NUDIX hydrolase -
INV104_RS08770 1675840..1676928 - 1089 WP_000719722.1 M50 family metallopeptidase -
INV104_RS08775 1676947..1677417 - 471 WP_000257107.1 DUF3013 family protein -
INV104_RS08780 1677708..1678160 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
INV104_RS08785 1678197..1678376 - 180 WP_001132276.1 type II toxin-antitoxin system HicA family toxin Toxin
INV104_RS08790 1678513..1678692 - 180 WP_001809903.1 hypothetical protein -
INV104_RS08795 1678857..1679075 - 219 WP_001273377.1 hypothetical protein -
INV104_RS08800 1679068..1680021 - 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
INV104_RS08805 1680612..1681883 + 1272 WP_001113209.1 replication-associated recombination protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6630.80 Da        Isoelectric Point: 10.8214

>T27095 WP_001132276.1 NC_017591:c1678376-1678197 [Streptococcus pneumoniae INV104]
MPMTQKEMVKLFTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 180 bp

>T27095 NC_017591:c1678376-1678197 [Streptococcus pneumoniae INV104]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCTTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT27095 WP_000961810.1 NC_017591:c1678160-1677708 [Streptococcus pneumoniae INV104]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT27095 NC_017591:c1678160-1677708 [Streptococcus pneumoniae INV104]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References