Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1156593..1157091 Replicon chromosome
Accession NC_017591
Organism Streptococcus pneumoniae INV104

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag INV104_RS06065 Protein ID WP_001809704.1
Coordinates 1156593..1156847 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag INV104_RS06070 Protein ID WP_000208080.1
Coordinates 1156849..1157091 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INV104_RS06050 1151865..1154333 - 2469 WP_001152988.1 DNA gyrase subunit A -
INV104_RS06055 1154527..1155513 + 987 WP_000204724.1 L-lactate dehydrogenase -
INV104_RS06060 1155773..1156546 - 774 WP_000731131.1 ion transporter -
INV104_RS06065 1156593..1156847 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INV104_RS06070 1156849..1157091 - 243 WP_000208080.1 hypothetical protein Antitoxin
INV104_RS06075 1157182..1157991 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
INV104_RS06080 1157993..1159342 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
INV104_RS06085 1159335..1160039 - 705 WP_000722076.1 response regulator transcription factor -
INV104_RS06090 1160094..1161269 - 1176 WP_000886148.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T27094 WP_001809704.1 NC_017591:c1156847-1156593 [Streptococcus pneumoniae INV104]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T27094 NC_017591:c1156847-1156593 [Streptococcus pneumoniae INV104]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT27094 WP_000208080.1 NC_017591:c1157091-1156849 [Streptococcus pneumoniae INV104]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT27094 NC_017591:c1157091-1156849 [Streptococcus pneumoniae INV104]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References