Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4293099..4293880 Replicon chromosome
Accession NZ_CP117376
Organism Salmonella enterica subsp. enterica serovar Newport strain RM041

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ16_RS21045 Protein ID WP_000625912.1
Coordinates 4293099..4293590 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ16_RS21050 Protein ID WP_001110450.1
Coordinates 4293587..4293880 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ16_RS21015 (4289360) 4289360..4289857 - 498 WP_001670425.1 FimD/PapC N-terminal domain-containing protein -
PQQ16_RS21020 (4289981) 4289981..4290811 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
PQQ16_RS21025 (4291013) 4291013..4291318 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ16_RS21030 (4291849) 4291849..4291992 + 144 Protein_4111 transposase -
PQQ16_RS21035 (4292009) 4292009..4292355 + 347 Protein_4112 Rpn family recombination-promoting nuclease/putative transposase -
PQQ16_RS21040 (4292636) 4292636..4292884 - 249 Protein_4113 IS481 family transposase -
PQQ16_RS21045 (4293099) 4293099..4293590 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ16_RS21050 (4293587) 4293587..4293880 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ16_RS21055 (4294197) 4294197..4294419 + 223 Protein_4116 hypothetical protein -
PQQ16_RS21060 (4294683) 4294683..4295558 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQQ16_RS21065 (4295555) 4295555..4295842 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ16_RS21070 (4295835) 4295835..4296017 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
PQQ16_RS21075 (4296037) 4296037..4296136 + 100 Protein_4120 hypothetical protein -
PQQ16_RS21080 (4296134) 4296134..4296382 + 249 Protein_4121 hypothetical protein -
PQQ16_RS21085 (4296677) 4296677..4297582 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4286188..4295842 9654


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270936 WP_000625912.1 NZ_CP117376:c4293590-4293099 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270936 WP_001110450.1 NZ_CP117376:c4293880-4293587 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References