Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4175923..4176439 Replicon chromosome
Accession NZ_CP117376
Organism Salmonella enterica subsp. enterica serovar Newport strain RM041

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag PQQ16_RS20400 Protein ID WP_000220579.1
Coordinates 4175923..4176207 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ16_RS20405 Protein ID WP_000212724.1
Coordinates 4176197..4176439 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ16_RS20385 (4171039) 4171039..4172691 + 1653 WP_000155055.1 alpha,alpha-phosphotrehalase -
PQQ16_RS20390 (4173100) 4173100..4175238 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ16_RS20395 (4175455) 4175455..4175919 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ16_RS20400 (4175923) 4175923..4176207 - 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ16_RS20405 (4176197) 4176197..4176439 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ16_RS20410 (4176517) 4176517..4178430 - 1914 WP_001212131.1 BglG family transcription antiterminator -
PQQ16_RS20415 (4178447) 4178447..4179187 - 741 WP_000779247.1 KDGP aldolase family protein -
PQQ16_RS20420 (4179184) 4179184..4180302 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ16_RS20425 (4180286) 4180286..4181419 - 1134 WP_000459949.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T270935 WP_000220579.1 NZ_CP117376:c4176207-4175923 [Salmonella enterica subsp. enterica serovar Newport]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270935 WP_000212724.1 NZ_CP117376:c4176439-4176197 [Salmonella enterica subsp. enterica serovar Newport]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References