Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3486113..3486733 Replicon chromosome
Accession NZ_CP117376
Organism Salmonella enterica subsp. enterica serovar Newport strain RM041

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ16_RS17230 Protein ID WP_001280991.1
Coordinates 3486515..3486733 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ16_RS17225 Protein ID WP_000344807.1
Coordinates 3486113..3486487 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ16_RS17215 (3481252) 3481252..3482445 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ16_RS17220 (3482468) 3482468..3485617 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ16_RS17225 (3486113) 3486113..3486487 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ16_RS17230 (3486515) 3486515..3486733 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ16_RS17235 (3486912) 3486912..3487463 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ16_RS17240 (3487580) 3487580..3488050 + 471 WP_000136181.1 YlaC family protein -
PQQ16_RS17245 (3488106) 3488106..3488246 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ16_RS17250 (3488252) 3488252..3488512 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ16_RS17255 (3488737) 3488737..3490287 + 1551 WP_000213138.1 EAL domain-containing protein -
PQQ16_RS17265 (3490518) 3490518..3490907 + 390 WP_000961287.1 MGMT family protein -
PQQ16_RS17270 (3490940) 3490940..3491509 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270932 WP_001280991.1 NZ_CP117376:3486515-3486733 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270932 WP_000344807.1 NZ_CP117376:3486113-3486487 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References