Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4350805..4351586 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ08_RS21530 Protein ID WP_000625912.1
Coordinates 4350805..4351296 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ08_RS21535 Protein ID WP_001110450.1
Coordinates 4351293..4351586 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS21495 (4346265) 4346265..4346612 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQQ08_RS21500 (4346588) 4346588..4348291 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQQ08_RS21505 (4348328) 4348328..4348903 + 576 WP_001188509.1 transcriptional regulator -
PQQ08_RS21515 (4349174) 4349174..4349248 - 75 Protein_4210 helix-turn-helix domain-containing protein -
PQQ08_RS21520 (4349628) 4349628..4349705 + 78 Protein_4211 porin family protein -
PQQ08_RS21525 (4349805) 4349805..4350557 + 753 WP_000842432.1 non-specific acid phosphatase -
PQQ08_RS21530 (4350805) 4350805..4351296 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ08_RS21535 (4351293) 4351293..4351586 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ08_RS21540 (4351903) 4351903..4352125 + 223 Protein_4215 hypothetical protein -
PQQ08_RS21545 (4352389) 4352389..4353264 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQQ08_RS21550 (4353261) 4353261..4353548 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ08_RS21555 (4353571) 4353571..4353786 + 216 WP_001595136.1 hypothetical protein -
PQQ08_RS21560 (4353794) 4353794..4354063 + 270 WP_077906657.1 hypothetical protein -
PQQ08_RS21565 (4354357) 4354357..4355262 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270917 WP_000625912.1 NZ_CP117373:c4351296-4350805 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270917 WP_001110450.1 NZ_CP117373:c4351586-4351293 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References