Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4243868..4244384 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQQ08_RS20955 Protein ID WP_000220574.1
Coordinates 4243868..4244152 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ08_RS20960 Protein ID WP_000212724.1
Coordinates 4244142..4244384 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS20940 (4238984) 4238984..4240636 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQQ08_RS20945 (4241045) 4241045..4243183 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ08_RS20950 (4243400) 4243400..4243864 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ08_RS20955 (4243868) 4243868..4244152 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ08_RS20960 (4244142) 4244142..4244384 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ08_RS20965 (4244462) 4244462..4246375 - 1914 WP_001212138.1 PRD domain-containing protein -
PQQ08_RS20970 (4246392) 4246392..4247132 - 741 WP_000779259.1 KDGP aldolase family protein -
PQQ08_RS20975 (4247129) 4247129..4248247 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ08_RS20980 (4248231) 4248231..4249364 - 1134 WP_274896628.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270916 WP_000220574.1 NZ_CP117373:c4244152-4243868 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270916 WP_000212724.1 NZ_CP117373:c4244384-4244142 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References